Impact of gestational diabetes on lipid profiling and indices of oxidative stress in maternal and cord plasma.
نویسندگان
چکیده
OBJECTIVE To study the effect of gestational diabetes mellitus (GDM) on indices of oxidative stress and lipid profiles in maternal and cord blood samples. METHODS Blood samples were collected from 40 normal pregnant women and 46 women with GDM during the period 1998 through to 1999 at the Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia. The GDM patients were subdivided into 2 groups: patients receiving insulin treatment (GDM-I, N=19) and patients under control diet (GDM-D, N=27). Plasma a- and y-tocopherols were estimated by high-performance liquid chromatography, whereas malondialdehyde (MDA) was analyzed by fluorometry. Serum lipids (low density lipoprotein, high density lipoprotein, total cholesterol, triglycerides, and total lipids) were determined by enzymatic colorimetry using automated clinical analyzer. RESULTS The results of lipid profiles in maternal serum showed no significant difference between GDM patients and controls; however, all the lipid constituents except total cholesterol were significantly reduced in the cord blood of GDM patients as compared to control subjects. a-tocopherol levels in the maternal plasma were not significantly different among the 3 groups, whereas, cord plasma a-tocopherol was significantly decreased in both GDM-D and GDM-I. Maternal y-tocopherol was found to be significantly increased in GDM-D and only insignificantly increased in GDM-I, but the cord y-tocopherol showed no appreciable changes. The level of MDA was 3-fold higher in maternal plasma as compared to cord plasma. However, neither the maternal plasma nor cord plasma showed significant differences in MDA levels between GDM patients and normal pregnant women. CONCLUSION A significant depletion of a-tocopherol in the cord blood of GDM patients is indicative of a possible oxidative stress in their fetuses. Further studies are warranted to examine a wider range of biochemical parameters to evaluate the potential risks of oxidative damage.
منابع مشابه
The Relationship between Levels of Lipids and Lipoprotein B-100 in Maternal Serum and Umbilical Cord Serum and Assessing Their Effects on Newborn Infants Anthropometric Indices
Background & aim: This study aimed to determine the relationship between lipid and apolipoprotein B-100 (apo B-100) levels in maternal and umbilical cord sera as well as the effects of these components on anthropometric measurements of newborn infants. Methods:This correlational study was performed on 85 appropriate for gestational age (AGA) newborns and their mothers. For analysis, 5 ml of m...
متن کاملCord Serum Lipid Profile of Infants of Diabetic Mothers
Background: Infants of diabetic mothers (IDM) is a critical issue in pediatrics, which is regarded as a major risk factor for birth trauma, respiratory distress syndrome (RDS), birth asphyxia, transient tachypnea of the newborn (TTN) and jaundice. IDM is also a risk factor for microvascular (e.g., ocular and renal complications) and macrovascular complications (e.g., cerebrovascular accident, a...
متن کاملAntioxidants and lipid peroxidation in gestational diabetes--a preliminary study.
Increased free radical activity in gestational diabetes (GDM) can lead to a host of damaging and degenerative maternal and fetal complications. Hence antioxidant levels in blood of GDM mothers and cord blood were estimated. Erythrocyte glutathione (GSH), superoxide dismutase (SOD) and thiobarbituric acid reactive substances (TBARS), plasma vitamins C and E and serum total glutathione-S-transfer...
متن کاملMaternal serum lipid levels in pregnant women with gestational diabetes mellitus (GDM) in comparison to normal pregnant women
Background: Even though hormonal changes in pregnancy have been associated with plasma lipid variation, is not yet understood the mechanism which pregnancy alters lipid metabolism. Materials and Methods: This prospective cohort study conducted between March 2011 and May 2012 in Shariati Hospital on 112 pregnant women with GDM and 159 healthy pregnant women. In order to determine lipids or li...
متن کاملEmbryo-Protective Effects Of Cerium Oxide Nanoparticles Against Gestational Diabetes in Mice
Context: Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. Objective: In this study, we used nanoceria as an antioxidant for amelioration of diabetic embry...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Saudi medical journal
دوره 25 7 شماره
صفحات -
تاریخ انتشار 2004